Oriol Mane Benach
Morphogenesis consists of a series of complex events, including symmetry breaking, cell differentiation and shape changes. The intrinsic capacity of stem cells to self-organize into functional tissues has enabled the development of in vitro biomimetic structures such as organoids and gastruloids. These approaches have improved the understanding of the mechanisms by which signaling pathways pattern tissues, but the role of tissue mechanics in cell fate patterning remains poorly understood. Differentiation patterns require the apparition of locations with strong expression of genetic markers previously homogeneously expressed, a process called symmetry breaking. Furthermore, fate is coupled to shape, as highly curved areas contain specific cell types. During my PhD I will explore the mechanical cues regulating stem cells morphogenesis in 3D. We aim at understanding how symmetry breaking and coupling between curvature and cell fate are controlled by mechanics of the growing tissue.